Abstrakt

An efficient survey and meta-analysis on the viability of stem cell treatment on bone brittleness in mouse models of osteogenesis imperfecta

Alessandra Carriero*

There's no remedy for osteogenesis imperfecta (OI), and current medicines can as it were in part adjust the bone phenotype. Stem cell treatment holds potential to progress bone quality and amount in OI. Here, we conduct a precise survey and meta-analysis of distributed thinks about to explore the viability of stem cell treatment to protect bone brittleness in mouse models of OI. Distinguished ponders included bone marrow, mesenchymal stem cells, and human fetal stem cells. Impact measure of break frequency, most extreme stack, firmness, cortical thickness, bone volume division, and crude engraftment rates were pooled in a random-effects meta-analysis. Cell sort, cell number, infusion course, mouse age, light, anatomical bone, and take after up time were considered as arbitrators. It was not conceivable to explore assist parameters due to the need of benchmarks of examination between the thinks about. In spite of the utilize of oim mice within the larger part of the examinations considered and the need of pretense mice as control, this ponder illustrates the promising potential of stem cell treatment to decrease breaks in OI.