Abstrakt

Association of ANXA1 and microRNA gene expression with cancer metastasis: A systematic review.

Chaoyang Xu, Liming Huang, Songxiang Wang

Metastasis is one of the major obstacles limiting the success treatment of cancer. Annexin A1 (ANXA1)
is a key member of the subfamily and belongs to the multi-gene family of annexins, which is known to
play an important role in cancer progression and metastasis. Although there were controversies
surrounding the relationship between ANXA1 and metastasis, the role of ANXA1 in cancer metastasis
has been increasingly recognized. Numerous ANXA1-related signaling pathways are involved in cancer
metastasis. Recently through microarray experiments demonstrate that ANXA1 could regulate
microRNAs (miRNAs) in cancer, such as miRNA-196a (miR-196a), microRNA-26 (miR-26) and
microRNA-562 (miR-562), which promoted cell proliferation and angiogenesis. ANXA1 could regulate
miRNAs to directly target NF-κB, estrogen receptor (ER) and angiogenesis gene transcripts. Thus,
ANXA1 mediates cancer metastasis may via regulation of miRNA signaling. This review describes the
mechanism by which ANXA1 contributes to cancer metastasis and summarizes new advances in
research in ANXA1associated cancer metastasis.