Abstrakt

Association of COVID-19 with genotyping ApoEe4 and APOBEC3B

Nagwa Ali Sabri, Mohamed Ahmed Raslan, Mona Alshahawey, Eslam Mansour Shehata

The novel Coronavirus disease 2019 (COVID-19), with no doubt is currently overwhelming the health care system capacity worldwide. Genetic implementation and practice may provide a ground for future studies on the role of human genetics in modulating the susceptibility to COVID-19 infection, disease severity and outcome. We will, briefly, overview and present the available scientific data, about ApoEe4 and APOBEC3B genotyping, and whether if they are associated with the pathogenesis of COVID-19 up to the current day. The novel coronavirus SARS-CoV-2 uses the ACE2 (Angiotensin Converting Enzyme 2) receptor for cell entry. ACE2 is highly expressed in type II alveolar cells in the lungs, where also ApoE is one of the highly co-expressed genes. ApoE was shown to be associated with susceptibility risk to viral, bacterial and parasitic infections.