Abstrakt

Association of NKX2-1 rs944289 SNP with DTC in sudanese population.

Fahmi Mahdi*, Nassr Eldin

The majority of malignant thyroid tumors derive from follicular epithelial cells. The Differentiated Thyroid Cancers (DTC) are papillary (PTC: 85% of cases) and follicular (FTC: 10% of cases) subtypes, and their etiology is still not well characterized. The transformation of normal into malignant tissue is a multifactorial process involving genetic and environmental factors such as radiation exposure. Some environmental factors such as hepatitis C infection or late and multiple pregnancies have been suggested as risk factors, but they have not been confirmed. Moreover, genetic components-for example proto-oncogenes, which encode receptor tyrosine kinases (RET) and small GT Pases (RAS)-may contribute to thyroid cancer formation in familial syndromes. However, none of these factors is thyroid specific, and therefore the identification of additional candidate genes is important for a better understanding of the pathogenesis of thyroid cancer.