Abstrakt

Bosnian burden of Brucellosis disease in Children for last ten years

Bajraktarevic Adnan

Background: The global burden of human brucelossis remains enormous and specially in Bosnia and Herzegovina. Infection can be transmitted to humans and children through direct contact with infected animals or their secretions, consumption of row milk and diary products, and inhalation of aerosols.
Objective: The aim of this review is to provide insight to epidemiology, etiology, clinical features, diagnosis and menagement of childhood brucelllosis.
Methods: Polymerase chain reaction (PCR) tests have been developed for the detection and rapid diagnosis of Brucella species in human blood specimens. A newly developed Enzyime-linked immune-sorbent assay (ELISA), Brucellacapt has demonstrated improved sensitivity compared to traditional agglutination methods.
Results: For brucellosis in children younger than eight years, administration of rifampin and TMP-SMZ for six weeks in the therapy of choice. The relapse rate appears to be approximately 4% or lower in Bosnia. The dominant manifestations were fever in 88.4%, joint pain in 61.1%  and hepatomegaly in 56.8% sick children. Organ affection was present in 51.0% of the children patients.
Conclusion: The goal of medical therapy in brucellosis to control symptoms as quickly as possible in order to prevent complications and relapses. Immunization is not an option for children patients and humans. The vaccine is attenuated for animals but not for humans and may cause disease in humans.