Abstrakt

Changing perspectives from the present and the future about the pathogenesis of hypertrophic cardiomyopathy.

Cetin Etsuko

A hereditary condition known as Hypertrophic Cardiomyopathy (HCM) is defined by nondilated left ventricles with retained or increasing ejection fraction and left ventricular hypertrophy that cannot be attributed to secondary causes. It is frequently asymmetrical, with the basal interventricular septum experiencing the most severe enlargement. About one-third of people have left ventricular outflow tract blockage at rest, and a second third can develop it under certain conditions. Myocyte enlargement and disarray, as well as interstitial fibrosis, are histologic characteristics of HCM. Additionally commonly linked to left ventricular diastolic dysfunction is the hypertrophy.