Abstrakt

Combination Treatment of Protease, DNase I, and Antibiotic for Biofilm-Involved Staphylococcus epidermidis Infections

Vincent Xin

Biofilms play a key role in bacterial resistance against antibiotics. Formation of biofilms enables S. epidermidis to become established in hospital environments and be a major cause of nosocomial infections . 50% of clinical isolated S. epidermidis from inpatients at Shanghai Renji Hospital are biofilm-forming, 95% are methicillin-resistant. Formation of biofilms and antibiotic-resistant strains render S. epidermidis infections a serious health issure—single antibiotic treatment often fails and removal of the infected catheter or prostheses is required. The development of more effective methods of treating biofilm-involved S. epidermidis infections will be a major step forward to counter such infections. To simulate S. epidermidis biofilm-involved infections, the two chosen clinical isolates were the most prevalent strains at Renji: biofilm-forming and methicillin-resistant.