Abstrakt

Edible plant-derived exosomes and their therapeutic applicatons

Polen Kocak, Ezgi Yagmur Kala, Merve Gunes, Naz Unsal, Hazal Yılmaz, Buse Metin, Fikrettin Sahin

Studies on exosomes -nano-sized vesicles containing nucleic acids, proteins and lipids- have increased over the past years due to their newly recognized role in cell-cell communication. While biogenesis and composition of exosomes from mammalian origin have been the focus of several studies, others demonstrated usage of these vesicles both as diagnostic and therapeutic tools. Recently, it has been shown that nanoparticles isolated from plant cells have very similar characteristics and secretion pattern with mammalian cells. These exosomes were isolated from different types of edible plants such as grapefruit, grape, ginger, lemon, and broccoli. Exosome-like nanoparticles from edible plants demonstrated to be the effective drug carrier which have role in decreasing liver damage and intestinal diseases. In this review, aspects of exosomes derived from edible plants, including their biogenesis and molecular composition as well as their therapeutic effects will be discussed in detail.