Abstrakt

Effect of bilateral and unilateral caloric vestibular stimulation in scopolamine induced dementia in Wistar albino rats

Jinu KV, Mukkadan JK, Archana R

This study was undertaken to provide preliminary evidence for beneficial effects of both bilateral as well as unilateral caloric vestibular stimulation as an alternative therapy for enhancement of cognition and motor activity in Scopolamine induced dementia in Wistar albino rats. 36 healthy, adult male Wistar albino rats with body weight ranging from 150-200 g were used in the current study. Donepezil is used as standard drug in this study. Donepezil was administered orally at a dose of 5 mg/kg for 14 days. Caloric vestibular stimulation was administered by irrigating the middle ear cavity with hot water with a temperature of 45 degree centigrade with the help of syringe for 30 days. In conclusion, even though our study proves both unilateral left and bilateral hot water vestibular stimulation is beneficial in Scopolamine induced dementic rats in improving spatial cognition as well as motor control, unilateral left vestibular stimulation was found to be more beneficial. We recommend further detailed studies in this area to explore mechanisms of action.