Abstrakt

Effect of risk factors on expression of vascular endothelial growth factor in precancerous lesions of gastric cancer

Ting Li, Xuezhu Jin, Jingrong Dong, Houbo Deng

Objective: To investigate the relationship between the various risk factors and Vascular Endothelial Growth Factor (VEGF) expression in the precancerous lesions of gastric cancer.

Methods: The patients with PLGC confirmed by gastroscope and pathology results were collected. The expression of VEGF was detected by immunohistochemical. The relationship of the expression of VEGF with smoking, drinking, diet condition of patients, personal history, and family history of Helicobacter pylori (H. pylori) infection was analysed.

Results: Single factor analysis showed that five risk factors (smoking, bile reflux, tumor family history, personal history of chronic atrophic gastritis and H. pylori infection) between VEGF positive group and VEGF negative group had statistically significant (P<0.05), the multiple factors logistic regression analysis showed that smoking (OR=3.386, 95% CI: 1.373~8.349), bile reflux (OR=3.027, 95% CI: 1.176~7.795), H. pylori infection (OR=3.884, 95% CI: 1.345~11.212) had affection on VEGF expression in PLGC.

Conclusion: Smoking, bile reflux and H. pylori infection were influencing factors for VEGF expression in PLGC.