Abstrakt

Effect of the hydroalcoholic extract from Lampaya medicinalis Phil. (Verbenaceae) on palmitic acid-impaired insulin signaling in adipocytes

Paulina Ormazabal

Female obesity is associated with menstrual disorders, infertility and recurrent miscarriages. Additionally, obesity is linked to metabolic pathologies such as dyslipidemia, Insulin Resistance (IR) and Type 2 Diabetes Mellitus (T2DM). Altered insulin function has been associated with abnormalities in female reproduction. Palmitic Acid (PA) is a saturated fatty acid with well-known IRinducing effects in vivo and in vitro. Lampaya medicinalis Phil. (Verbenaceae) is a small bush that grows in the North of Chile. The infusion of the plant has been used by local ethnic groups to treat and cure diseases. The aim of this study was to assess in vitro the effect of the Hydroalcoholic Extract of Lampaya medicinalis (HEL) against PA-induced IR in adipocytes from the 3T3-L1 cell line.