Abstrakt

Effects of different anesthesia and analgesia methods on postoperative Tlymphocyte, interleukin and hormone level of patients with esophageal cancer operation

Mingxin Chen, Hongyin Du

Objective: This study was aimed to explore effects of different anesthesia and analgesia methods on postoperative T lymphocyteinterleukin and hormone level of patients with esophageal cancer operation.

Methods: From December 2015 to December 2016, a total of 134 patients with esophageal cancer were selected from our hospital as the study objects. All patients were divided into control group (n=67) and observation group (n=67). Patients in the control group were treated with epidural block anesthesia while patients in the observation group were treated with epidural block anesthesia combined with general anesthesia. T lymphocyteinterleukin and hormone level of patients in two groups at different periods of time (C1: 30 min before anesthesia, C2: skin incision of 2 h, C3: 2 h after operation, C4: 24 h after operation, C5: 48 h after operation) were analysed and compared.

Results: There were more CD4+ T lymphocytes in patients from observation group than those from control group at all periods (p<0.05). More CD8+ lymphocytes in the control group at C3 and C4 period (p<0.05), no difference at C1, C2 and C5 (p>0.05). Interleukin level in patient from control group was significantly lower than that in patients from observation group (p<0.05). Both PRL and GH level were lower in observation group at C2-C5 period and no difference at C1 stage and no significant difference of COR level was observed between two groups at all periods.

Conclusion: Epidural block anesthesia combined with general anesthesia is preferable during esophageal cancer operation.