Abstrakt

Epithelial-to-mesenchymal transition is promoted by Mnt.

Farlane Mac

When a tumour develops metastatic spread, the survival indices in epithelial neoplasms, like laryngeal carcinoma, rapidly decline. Epithelial-to-mesenchymal transition (EMT), a molecular phenomenon that typically manifests during embryogenesis, is reactivated at the initial stage of metastasis when tumour cells invade the nearby stroma. The hallmarks of this phenomenon include tumour cells losing their epithelial characteristics and acquiring mesenchymal characteristics that increase their ability to migrate. Complex molecular pathways that control the expression of key molecules influencing the tumor's potential for metastasis mediate Loss of adhesion, cytoskeleton remodelling, evasion of immune surveillance and apoptosis, upregulation of metalloproteinases, neovascularization, acquisition of stem-cell characteristics, and activation of tumour stroma are some of the effects of EMT theory apply to laryngeal carcinoma, a tumour with significant morbidity and mortality.