Abstrakt

Influence of Curcuma longa rhizome powder on morphofunctional parameters of kidneys in rats with an experimental model of diabetes mellitus

Roman Aizman

The effect of turmeric rhizome powder(Curcuma longa) on water-mineral balance, morphological structure, and kidney functions was studied in experiments on rats with an alloxan-induced model of type 1 diabetes mellitus. Three groups of animals were studied: control ones  and diabetic rats: on standard diet  and animals, which got Curcuma longa at the amount of 2% of the food mass (D+Cl). It was found that in diabetic rats the plasma sodium and potassium concentrations did not change, while urea concentration (from 18.2±1.6 to 29.5±3.2 mmol/L) and creatinine level (from 0.8±0.01 to 1.4±0.08 mmol/L) significantly increased compared to similar parameters of healthy animals (C). The other plasma parameters between diabetic animals on a standard feed  and the rats, consuming turmeric (D+Cl), did not differ. The study of the basal hydro- and ionouretic renal function in diabetic rats did not reveal a significant increase in urine output in the experimental groups. Glomerular filtration rate and level of tubular reabsorption did not significantly differ between groups as well as the fractional potassium (22.2±4.9 and 27.3±3.0 %) and sodium (0.4±0.11 0.6±0.09%) excretion. But in rats with DM the characteristic damage of renal tissue consisting in occurrence of protein, fibers, collagen, sulfatic glycosaminoglycans and a sclerosis of nephritic little bodies between leafs of Shumljansky-Boumen’ capsule was marked. The use of turmeric optimized the morphological processes in the kidney of animals with diabetes mellitus and reduced structural damage in the renal bodies. These results of morphohistochemical and functional analysis of kidneys suggest that the consumption of turmeric by animals with diabetes reduces the level of structural disorders in the nephrons, but does not cause significant changes in kidney functions in conditions of spontaneous urination.