Abstrakt

Is psoriasis a high risk factor for tumors?

Xibao Zhang

Psoriasis is a chronic, autoimmune cause of the inflammatory disease, affecting about 2% to 3% of the world’s population 1. The disorder is characterized by abnormally infiltration and activation of T cells and various other immune cells, which cause hyperproliferation of keratinocytes and inflammatory processes. Common comorbidities of psoriasis include psoriatic arthritis, inflammatory bowel disease, cardiovascular disease and metabolic syndrome 2. There is accumulating evidence suggesting a positive association between psoriasis and cancer. Although conflicting data on the risk of specific cancers in patients with psoriasis, the increased risk of some cancers in psoriasis patients has been shown. Why there's a link between psoriasis and cancers. Here are the possible explanations, the co-risk factors psoriasis and tumors, the chronic inflammatory nature of the disease, and the immune modulatory treatments.