Abstrakt

Mechanisms of adrenal and adrenal cortical tropic hormone efflux and health consequences

Lusi Rosy*

Current knowledge of control of the hypothalamic-pituitary-adrenal (HPA) axis is significantly improved during the ensuing ten years. In order to deliver a dynamic output suitable again for response characteristics of their tumor sites, autonomic cardiovascular circuitry must combine a wide range of internal and external inputs. Such a physiological system includes the Hypothalamic - pituitary - adrenal. Recent research has established that now the main products of this network, the adrenal glucocorticoids corticosterone in rodents and mostly cortisol in humans, exhibit identical conditions and consist of pulses of variable amplitudes that are produced by a ophthalmic pulse generator. In each component of the axis, such as the adrenal cortex, oscillating endogenous glucocorticoid signals interact with regulatory networks that can further alter the inspiratory secretion of hormones.