Archives of Industrial Biotechnology


Nucleic acid aptamers and its applications in microbial infections.

Jonghoe Heonyong

Due to the rising prevalence of germs that are resistant to a wide range of drugs, the complexity of treatment and rising healthcare expenditures, treating bacterial infections is a significant challenge today. Furthermore, there aren't many novel antibacterial therapies. Monoclonal antibodies are being replaced by oligonucleotide aptamers, which are single-stranded DNAs or RNAs having a target-selective high-affinity property. The use of aptamer-based systems in drug delivery systems and the reduction or inhibition of the effects of bacterial toxins have been proven to be effective methods for treating microbial illnesses. They also exhibit promising antibiofilm and antibacterial capabilities. The therapeutic uses of aptamers in infections are the main subject of this review.