Abstrakt

Personalized medicine: Introduction of genomics, proteomics and metabolomics in novel drug development and therapy

Baharudin Ibrahim

Personalised medicine is a medical model designed to customize drug therapies to individual patients using their distinct characteristics including demographics, medical histories and most importantly their molecular information (genetic, protein and metabolic profile). Current drug development is principally based on epidemiological studies of large cohorts targeting development of so-called blockbuster medicines.This one-size-fits-all model do not account for individual differences in terms of genetics, proteins and metabolites thus may increase cost, adverse drug reactions and contribute to drug development failure in large clinical trials.