Abstrakt

Proangiogenic factors in Cancer: A briefing

C N V Akhila

Angiogenesis plays a key role in the progression of cancer. The rapid proliferation of tumor cells is mainly due to disruption of cellular homeostasis, resulting in up regulation of angiogenic factors. Initiation of cancer is from a single cell or a small group of cells often called field cancerization. Within a period of time after the clone of cells emerges to adapt to the primary site further promotion of tumor cells occurs and the cells undergo various modifications. Tumor cells attain stability and some of the external as well as internal, tumor cells itself result in neovascularization and angiogenesis.