Abstrakt

Study of some cord blood markers as early predictors of neonatal sepsis.

El Farargy MS, El-sharkawy HM, Attia GF

Study of some cord blood markers as early predictors of neonatal sepsis. This prospective casecontrol study was conducted on 85 neonates who were followed up in the Neonatal Intensive Care Unit (NICU) from June 2016 to December 2017. Studied neonates are divided into 3 groups: Group 1 (Control) are 10 cases in which cord blood level of IL 6 and IL 8 are normal at birth and (C-Reactive Protein) CRP was negative at birth and still negative after 3 days. Group 2 (Suspected) are 45 cases in which cord blood level of IL 6 and IL 8 are elevated at birth and CRP was negative at birth then become positive after 3 days. Group 3 (Infected): are 30 cases in which cord blood level of IL 6 and IL 8 are elevated at birth and CRP was positive at birth and still positive after 3 days. There was significant increase in suspected, infected groups as compared to control group as regard CRP with P-Value 0.001*. The level of IL-6 is significantly higher in suspected, infected group than control group with P-Value 0.001*. The level of IL-8 is significantly higher in suspected, infected group than control group with P-Value 0.001*. The IL 6 and IL8 are more sensitive than CRP in early prediction of neonatal sepsis so we conclude that IL 6 and IL8 levels should be done for early detection of neonatal sepsis which will lead to early diagnosis of neonatal sepsis with early treatment and subsequent better prognosis.