Abstrakt

Synthesis and biological evaluation of tetrahydrobenzo[b]pyran derivatives as potential anti-ovarian cancer agents

Chuan Wang

The synthesis and characterization of four novel pyran derivatives (1-4) have been done by means of IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The antitumor activities of the four compounds were studied in order to inhibit three human ovarian cancer cells, which are OVCAR, HRA and COC1, growth by MTT assay. It was found that compound 4 exerted much more potent activities against all of these cell lines than other compounds did.