Abstrakt

Type 1 Diabetes Vaticination and progression

KM Gillespie,

Multiple island autoimmunity increases the threat of diabetes but not all individualities positive for two or further island autoantibodies progress to the complaint within a decade. The Crawler study seeks to harmonize data from longitudinal studies to identify the characteristics of a slow progression to type-1 diabetes. Samples from 125 individuals with multiple islet autoantibodies (IAA, GADA, IA-2A and ZnT8A) for more than 10 years without progression were available from four studies (Bart-Oxford (BOX), UK; BABYDIAB, Germany; DAISY and Pittsburgh Diabetes, USA). Individuals enrolled in BOX provided Rapid Progresso