Abstrakt

Upregulation of SOCS1 and SOCS3 in pediatric patients with Henoch-Schoenlein purpura

Fengying Wang, Xiaozhong Li, Lusheng Huang, Kang Xu

Suppressors of Cytokine Signaling (SOCS) family members are inhibitors of cytokine signaling pathways. Emerging evidence suggests the involvement of SOCS1 and SOCS3 in a variety of diseases, including allergy, autoimmune diseases, and inflammation. This study aimed to investigate the expression of SOCS1 and SOCS3 in the development of Henoch-Schoenlein Purpura (HSP) in children. Peripheral Blood Mononuclear Cells (PBMC) were isolated from children with HSP (HSP group, n=20) and healthy children (control group, n=15). The mRNA and protein levels of SOCS1 and SOCS3 in PMBC were detected by real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Western bot analysis. The results showed that the mRNA and protein levels of SOCS1/3 were upregulated in HSP group compared to control group (P<0.01). These data demonstrate that SOCS1 and SOCS3 are upregulated in children with HSP, and suggest that SOCS1 and SOCS3 are involved in the pathogenesis of HSP.