Abstrakt

Vaccine against S. pyogenes.

Luiza Guilherme

StreptInCor, a candidate vaccine against S. pyogenes is based on protective 55 amino acids residues of C-terminal portion of the M protein. Experimental assays have demonstrated that the StreptInCor peptide induces high titers of opsonic and neutralizing and protective antibodies in outbred immunized mice. Using HLA class II transgenic mice, it was possible to evaluate the immunogenicity and safety of the StreptInCor vaccine epitope for a period of one year.