Abstrakt

Yigu decoction has an influence on quantitative proteomics

Huang Cho

Osteoporosis (OP) is a systemic bone disease marked by a loss of bone mass, degradation of the microstructure of bone tissue, increased brittleness, and an increased risk of fracture. OP is associated with significant consequences and has a high incidence rate and a protracted illness course. Yigu Decoction (YGD) is a traditional Chinese medicine chemical prescription used to treat OP. In OP, however, the process is unclear. The possible bone-protective mechanism of YGD was investigated in an osteoporotic rat model using a Tandem Mass Tag (TMT) quantitative proteomics approach. By modulating target proteins involved in many signalling cascades, YGD can considerably improve the Bone Mineral Density (BMD) of osteoporotic rats and may perform a therapeutic role. As a result, these findings contribute to a better understanding of the OP mechanism and provide an experimental foundation for the clinical use of YGD in OP treatment. Low bone mass, bone tissue breakdown, and discomfort are all symptoms of Osteoporosis (OP).