Abstrakt

USE OF GREEN NANOTECHNOLOGY FOR THE PRODUCTION OF MEDICINE AND TO CHECK ITS BIOAVAILABILITY AND THERAPEUTIC APPLICATIONS IN THE DEVELOPMENT OF NEW GENERATION DIAGNOSTICS AND TREATMENT

Ramneet Kaur1*, Dibita Mandal2, Juveria Ansari2, Prachi R Londhe2, Vedika Potdar2, Vishakkha Dash2

Green synthesized particles have shown to possess properties such as antimicrobial, antioxidant and cytotoxicity to tumor (cancer) cells. The Gold Nanoparticles (AuNPs) and Silver Nanoparticles (AgNPs) are important metallic nanoparticles of primary focus. AuNPs have good bioconjugation properties which contribute to its attachment affinity to the in vivo cells. This property of AuNPs has helped in the production of bio stable drugs that do not easily disintegrate in the biological fluids or physiological pH change. AgNPs have a good cell membrane penetration power which has helped in the synthesis of drugs with high antimicrobial efficacy. The problem of antimicrobial agent resistance by the pathogenic microorganism can be overcome to certain extent with the use of green synthesized AgNPs. The importance of AuNPs and AgNPs has been described further in this review paper. The AuNPS and AgNPs have been produced using plants, fruits, leaves extracts as well as some species specific bioresources as the stabilizers. Nano-coupled enzymes have shown to have good bioavailability properties. Nanocarriers have considerably helped in prolonging the acting period of the therapeutic and antioxidant enzymes thus elevating the efficacy of working on the target cells. Carbon based nanorods have helped to improve the manufacturing conditions of the biomaterials so that they are more biocompatible with the in vivo conditions and cells.